Circadian rhythm and its role in human disease

Are you an early riser or a night vigilant? It happens for each of us that we may awake before the alarm clock rings. This is a function of biological clock. In this article we want to know if disruption in circadian clock that occurs for shift workers or in jet lags has any effect on appearance of diseases such as cancer, diabetes or obesity? In fact, we must study if there is any link between this disruption and over weighted ness or cancer or diabetes. Biological rhythms exist in all organisms from cyanobacteria to human. Organisms use this rhythm to coordinate their physiology. Biological clock has nine genes and the productions of these genes regulate circadian rhythm. There is more than one circadian clock in each organism. As it is proven disruption of cell cycle causes cancer. Transition from different phases of cell cycle that is done by CDKs, CKIs and expression of CDKs, CKIs Tumor suppressor genes are controlled by clock genes and show circadian rhythmicity in their expression thus disruption in circadian rhythm causes cancer. In this study we survey the effects of disruption of circadian rhythm in some cancers such as colon cancer, colorectal cancer, skin cancer, liver cancer and breast cancer then we check if this disruption has any effects on obesity and diabetes as well?
Lack of sleep is associated with obesity and also, the increase of abdominal fats elevates the risk of diabetes. However we cannot suggest that disruption of circadian rhythm will definitely increase the risk of diabetes. Disruption may make the person susceptible for the mentioned diseases but has not shown to have direct effect on these diseases.